Transformed Migraine Headache http://www.gather.com/viewArticle.jsp?article... Transformed migraine headache is extremely difficult to treat, and acts more like a chronic pain syndrome than a migraine in terms of its poor response to typical migraine drugs. Some researchers believe that years of chronic, frequent migraines can cause permanent scarring or other changes in the brain creating this type of intractable CDH, which may not be curable.